2014-2013
首页  科学研究  发表论文  2014-2013

A convenient method for synthesis of polyfunctional dihydropyrroles spiro-fused oxindole-2-ones via an organocatalytic tandem Michael/cyclization sequence(Tetrahedron Letters 2014,55 , 7110–7113)

Graphical Abstract

 

ABSTRACT

A new methodology was developed for the synthesis of spirocyclic oxindoles bearing polyfunctional dihydropyrrole units via an organocatalytic tandem Michael/cyclization sequence. Products bearing adjacent quaternary-tertiary stereocenters were smoothly obtained in high yields (up to 97% yield) with excellent diastereoselectivities up to >20/1.